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1, 2, and 3-ARs, which are coupled to G s , lead to activation of adenylyl cyclase, increasing levels of the second messenger cyclic AMP (cAMP) to promote Protein kinase A (PKA) activation (83) (Figure 2)

The authors thank the members of the Data Safety and Monitoring Board, Boston, MA, and Bangalore, India (Ellis Neufeld, Chair, Leslie Kalish, Arun Mhaskar, and Kishore Phadke)