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Similarly, mutations in ATP-binding cassette transporters, such as ABCA1 and ABCG1, disrupt cholesterol efflux pathways and promote cholesterol ester accumulation in macrophages, contributing to the pathogenesis of atherosclerosis and foam cell formation

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Cholesterol is an essential compound because it is a precursor for sex hormones, such as progesterone

Song et al., Dual enzyme-like activities of iron oxide nanoparticles and their implication for diminishing cytotoxicity