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Cu 2+ overload in macrophages stimulates IKK-mediated phosphorylation of IB, triggering NF-B nuclear translocation and subsequent upregulation of IL-1, TNF-, and IL-6 expression (85)

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The peptide stimulates glycogenolysis (glycogen breakdown) and gluconeogenesis (synthesis of glucose from non carbohydrate sources), inhibits glycogenesis (glycogen synthesis) and glycolysis, overall increasing hepatic glucose output and ketone body formation

Mutations in EPCAM cause silencing of the gene MSH2

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