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Cell-intrinsic insulin signaling defects in human iPS cell-derived hepatocytes in type 2 diabetes

These coq mutants are thus incapable of cellular respiration and fail to grow in a non-fermentable medium

, Zheng X., Tang H., et al

In the centrilobular hepatocytes, there was substantial proliferation of rough endoplasmic reticulum, as shown by electron microscopy with slightly less than half of the periportal hepatocytes showing rough endoplasmic reticulum proliferation

Relevance of Experimental Doses to Human Exposure A major challenge in interpreting the toxicological evidence on MNPs is the disconnect between the high, often acute, concentrations used in experimental models and the lower, chronic exposures experienced by humans in real-world settings

This method helps treatments take effect more quickly and reliably than pills