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As liver fibrosis is the result of prolonged chronic inflammation, a significant body of research now suggests that the process of liver fibrosis is already initiated even before apparent manifestations of liver fibrosis (Briand et al

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for instance, the exact cellular localization of Scly, whether Scly directly transfers Se to selenophosphate synthetase 2 (SEPH2) or there are other proteins involved, and the exact role of minor intermediates such as selenohomocysteine (trans-selenation pathway) or Se bound to glutathione (selenite reduction pathway) in Se turnover (Seale et al., 2018a

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