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Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide), belonging to AngIV-related peptides, is an allosteric activator of HGF and enhances MET signaling in the brain (McCoy et al., 2013)

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The consistency of GSH reduction across sexes suggests that oxidative stress involvement in migraine is not primarily driven by sex-specific factors, though our study was not powered to detect subtle sex differences in effect magnitude

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