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This dose-tolerability relationship provides useful guidance for clinical protocol development

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This makes it convenient when one needs to mix a multi-dose medication (for example, reconstituting a vial of medication that will be used for several injections over a course of days)

The needle may be misleading

B12 supports brain function by promoting red blood cell production and oxygen flow

Therefore, human plasma TdR level does not appear to be a useful PD phenotypic marker for TS inhibition