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Avoid cross-linking agents in the final binding step unless coordinated

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For example, GPX4 inhibitor-Bufotalin (BT), through facilitating the ubiquitination and degradation of GPX4, induces ferroptosis of non-small cell lung cancer (NSCLC) cells [280]

Regulation of GPx-1 Expression and Activity GPx-1 is subject to transcriptional, post-transcriptional, translational, and post-translational regulation (Fig