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After incubation on ice for 8 min, the lysates were centrifuged at 13,000 g for 3 min at 4 C

PMCID: PMC3667691

Although systemic inflammation is known to modulate iron metabolism, such as interleukin-6 (IL-6) stimulating hepcidin synthesis and subsequently downregulating FPN1, this has been observed primarily in hepatic tissues (95)

doi: 10.3389/fphar.2022.847113 Received 01 January 2022 Accepted 14 April 2022 Published 02 June 2022 Volume 13 - 2022 Edited by Rosa Ventura-Martinez, Universidad Nacional Autnoma de Mxico, Mexico Reviewed by Paramita Basu, University of Pittsburgh, United States Patricia Garcia-Lopez, National Institute of Cancerology (INCAN), Mexico Mariano Martinez-Vazquez, Universidad Nacional Autnoma de Mxico, Mexico Updates Copyright 2022 Yen, Zhao, Yu, Zhu and Li

This is a stressor for the body, causing hypoxia of intestinal cells due to redistribution of blood in the body, hyperthermia and dehydration [158, 159]