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Both conditions involve complex pathological mechanisms that include primary mechanical damage followed by secondary injury cascades involving inflammation, oxidative stress, and regulated cell death pathways such as ferroptosis (217, 218)

Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimers disease neurons

DKD, characterized by persistent proteinuria and/or a progressive decline in glomerular filtration rate, is one of the most prevalent complications of DM and a leading cause of end-stage renal disease (ESRD) 3

Pharmacokinetic Parameters The elimination phase after the single NAC administration could not be defined for two Caucasian participants according to the established condition (quality of extrapolated pharmacokinetic parameters as demonstrated by a determination coefficient, R 2 1000 L), indicating that the drug was able to reach deep tissue compartments

Statements Author contributions YL: Conceptualization, Writing original draft

Molecular pathways: the metabolic regulator estrogen-related receptor as a therapeutic target in cancer