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Nonenzymatic oxygen activation and stimulation of lipid peroxidation by doxorubicin-copper

In comparison to cholesterol liposomes (C-LPs), ginsenoside Rg3-LPs not only markedly enhance cellular uptake and the capacity to penetrate glioma spheroids (C6) cells, but also significantly strengthen the active targeting of glioma and the intertumoral diffusion ability in vivo [629]

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Small human studies support the biological plausibility of both approaches, but there are no robust head-to-head clinical trials proving that one produces better health outcomes than the other