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IGFBP-2 was shown to be specifically involved in endothelial recruitment, angiogenesis, and metastatic colonization, an effect that required the presence of both IGF-1 and IGF1R [40]

10.1038/s41586-021-03539-7 114 MaoL.YouJ.XieM.HuY.ZhouQ

Pain 21 , 6172 (2017)

Nonetheless, the combination of NTBC and restricted dietary therapies as an approach to this once fatal pediatric disease remains a cause for optimism

Breastfeeding is usually not contraindicated and could be allowed for a period depending on whether treatment reintroduction is needed for mass control (strong)

Subsequently, immunohistological analysis mainly highlighted active immunostaining at the cochlear second turn, especially on outer hair cells