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(Diagram illustrating the mitochondrial genome, the production of the MOTS-c peptide within the mitochondria, and its subsequent translocation to the cytoplasm and nucleus to influence cellular processes.) The Key Pathway: How MOTS-c Activates AMPK The primary MOTS-c mechanism of action involves the robust activation of a critical enzyme: 5 AMP-activated protein kinase, or AMPK

Jul 2016;31(7):791-8

It also modulates the Nitric Oxide (NO) system, providing a potent cytoprotective effect on the endothelium and gastrointestinal mucosal lining

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(2023) 13:e064376

The study found that 40% of U.S