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2021 Aug 21;13(8)

These genes stimulate the production of antioxidant proteins, phase I oxidation, reduction, and hydrolysis genes, phase II detoxifying enzymes such as glutathione s-transferases (GSTs), NADPH-generating enzymes, drug transporters, and stress proteins involved in heme and metal metabolism, such as heme oxygenase 1 (HO-1)
[DOI] [PubMed] [Google Scholar] 500.Thomas T, Gori F, Khosla S, Jensen MD, Burguera B, Riggs BL
In cases 2 and 3, at each subsequent treatment cycle, the frequency of peri-plaque injections with PTX 100 mg was gradually reduced

Some healed plaques do not cause any clinical events, but others undergo structural changes over a period of days to weeks that eventually occlude the vessel, resulting in an acute ischemic event (eg, a heart attack) long after the initial plaque destabilization

NMJ dysfunction and instability is a frequently encountered electrophysiologic finding in the evaluation of ALS [282]