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Regulation of the Non-Oxidative Phase: Availability of Substrates: The non-oxidative reactions are reversible and are primarily regulated by the availability of their substrates (Ribulose-5-phosphate, Xylulose-5-phosphate, Ribose-5-phosphate, Fructose-6-phosphate, Glyceraldehyde-3-phosphate)

Although pediatric cases of T-ALL have a cure rate exceeding 80% with current intensified chemotherapies, the outcome of T-ALL patients with primary resistant or relapsed leukemia remains extremely poor (Winter et al., 2015)

Moreover, because of down-regulating the expression of CXCR4 in B cells, B cell motility was reduced which potentially resulted in the expulsion of B cells from BM

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