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Trial registration This trial has been registered with ClinicalTrials.gov, number NCT 01476007, and under EUDRACT number 2010-024129-20

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However, despite promising efficacy and safety data, it did not advance to Phase 3 trials or obtain regulatory approval for therapeutic use

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Effective July 1, 2025, CMS implemented new NCCI PTP edits affecting how 90480 interacts with Medicare G-codes

Higher concentrations (3-4%+) are for experienced users who have established tolerance