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In patients with MASLD-related cirrhosis, exercise may be particularly important, as weight loss and physical activity have the potential to slow or reverse hepatic fibrosis, offering benefits beyond pain management alone

The sample was incubated with an equal amount of analytical buffer at room temperature for 30 min

Distinct mechanisms of adipocyte elimination in metabolic disease AT undergoes several forms of cellular elimination under metabolic stress: mitochondrial-dependent apoptotic pathways, inflammatory cell death via receptor-interacting serine/threonine-protein kinase 3 (RIPK3)/Mixed lineage kinase domain-like protein (MLKL) signaling, and inflammasome-triggered membrane disruption through specific molecular cascades (84)