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It works by exposing the immune system to gradually increasing doses of whole allergen proteins, eventually inducing tolerance

Reduced nighttime waking: Users often report fewer awakenings during the night, leading to a more continuous and restful sleep cycle

Since the nuclear respiratory factor 1 (NRF-1) regulates the Tfam promoter activity and maintains mt-DNA copy number in vivo 24,25 , we assessed its expression pattern and found increased NRF-1 levels preceding those of TFAM in NaBt-treated cells (Fig