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Indeed, over-expression of arrestin 2 induces a selective uncoupling of DOR and KOR and reduces inhibition of ACase (Cheng et al., 1998)

Fatigue and sluggishness can make daily life challenging

These include mild or moderate nausea, diarrhea, vomiting, constipation, appetite loss, belching, heartburn, reflux and stomach pain

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Further research is necessary to fully characterize its mechanisms of action and broader applications within biomedical science

Best Pract Res Clin Endocrinol Metab (2019) 33:101290
