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Notably, TAP1 gene polymorphisms (I333V and D637G) in MB were linked to a reduced risk of high-grade intraepithelial neoplasia, offering actionable insights for clinical management and resource allocation

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Melatonin expresses anti-inflammatory and antioxidant properties, and regulates different biological functions such as sleep, circadian rhythm, immunity, reproduction and blood pressure control

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The response to ER stress plays a pivotal role in MTX-induced apoptosis, where MTX primarily triggers ER stress via the PERK/CHOP pathway (Song et al., 2021)

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Excessive ROS may contribute to oxidative injury through alteration of cellular components

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Arch Ophthalmol 124:9951001

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Blackmon SH, Correa AM, Wynn B, Hofstetter WL, Martin LW, Mehran RJ, Rice DC, Swisher SG , Walsh GL, Roth JA, and Vaporciyan AA

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