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Mature spermatozoa themselves have also been suggested to play a critical role in the production of ROS, probably as an end-product of cellular metabolism ( (58)

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HIF-1 (hypoxia-inducible factor-1) promotes macrophage necroptosis by regulating miR-210 and miR-383

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Indeed, the hallmark type 2 cytokines IL-4 and IL-13 reduce the expression and activity of GPX4, while increasing 12/15- lipoxygenase [336] or the human ortholog 15- lipoxygenase [337], thus increasing ferroptosis susceptibility of immune cells (Fig

Presently, the treatment of choice includes chemotherapy and allogeneic stem cell transplantation [1]