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Sublingual absorption is at least partially passive, it doesn't require stomach acid or intrinsic factor, and high doses leverage a small passive-diffusion absorption pathway that operates independently of the intrinsic factor system

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[DOI] [PubMed] [Google Scholar] 19.Martinez-Martin P., Rodriguez-Blazquez C., Kurtis M.M., Chaudhuri K.R., Group N.V

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Stage 3: Method-of-Use Patent Expansion (Years 5-20 from NDA) Post-approval clinical research frequently generates new uses for approved drugs, either as single agents in new indications or as components of combination regimens

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