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doi: 10.2337/dc15-0165

163 On the other hand, COX-2 is generally synthesized in response to inflammatory stimuli in many tissues including prostate, immune cells (T-cells, B-cells, monocytes), and stomach, but is also constitutively expressed in the brain, lungs, gut, thymus, kidneys, and blood vessels

These differences suggest that FM patients may have alterations in brain function and activity that contribute to the development of FM symptoms 85,86