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The optimal concentration (30 g/ml) was therefore selected for follow-up studies that showed an enhanced rate of neuronal differentiation, dendrite complexity, axonal development and synaptogenesis, with all responses consistent with the hormetic dose response

52 In 2023, the Nobel Prize in Physiology and Medicine was awarded to Katalin Kariko and Drew Weissman for pioneering nucleoside base modification technology to decrease mRNA immunogenicity, further highlighting the critical role of chemical modification technologies in developing mRNA vaccines

Besides that, epidemiological studies have described a correlation between changes in the intestinal microbiota and susceptibility to the development of airway allergies
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