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In some previous studies, it was reported that a high concentration of CaOx crystals induced an excessive burst of autophagy and ERS (14-16), which led to the subsequent oxidative stress reaction and eventually induced the formation of kidney stones

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Additionally, paeonol, the main active component of Paeonia lactiflora Pall., suppresses the viability and metastasis of human lung cancer cells by up-regulating miR-126-5p expression, which subsequently downregulates its target gene ZEB2, a key EMT inducer that represses E-cadherin expression [328]

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