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Scheme of T3M4 stably expressing luciferase reporter with wild type PPAR 5UTR (WT) or PRTE mutated PPAR 5UTR (Mut)

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553 The treatment of HLH basically comprises two phases: controlling overwhelmed CS with chemotherapy to eliminate activated T cells and inhibit inflammatory cytokine production, and subsequently replacing the defective immune system by allo-HSCT

Mutants with replication and survival defects will sometimes show more robust virulence defects in murine models compared to ex vivo assays given the more restrictive physiology and multicycle infectious nature [61]