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10.1016/1044-7431(92)90006-N
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Injecting untested, unregulated peptides is, at best, a large waste of money and, at worst, a path to long-term side effects that we do not yet understand
Notably, supplementing NADPH and using a pharmacological inhibitor of aldose reductase an enzyme using NADPH oxidase for the formation of sorbitol in high-glucose conditions - successfully restored the sensitivity to LPS-induced NET formation in high glucose conditions, while reducing high glucose-induced cytosolic ROS production, neutrophil elastase secretion and spontaneous NET release (Joshi et al., 2020) (Table 4)
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