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The operational challenge is that the FDA-approved HRT formulary doesnt cover every patientand the patients it doesnt cover are arriving in numbers that compounding pharmacies were not built to handle through phone calls and fax machines

Moreover, several studies demonstrated that proIGF-1s remained unprocessed in cultured cells, whether endogenously expressed IGF-1 isoforms (HepG2, K562 and HeLa cells 8,9 ) or that were exogenously transfected with IGF-1 isoforms (HEK293 cells 7 )

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