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Comparative study of extraction, purification and estimation of bromelain from stem and fruit of pineapple plant
The top three research priorities were found to be (1) understanding the biological mechanism behind PEM and how this can be treated or managed (2), which existing drugs used for other conditions would be useful in treating ME/CFS, and (3) finding accurate and reliable diagnostic testing for ME/CFS

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Most evidence remains preclinical, with limited controlled human research currently available

Understanding these distinct mechanisms is essential when considering whether these treatments can be used concurrently

DA-depleting agents and DA receptor antagonists effectively reduced abnormal movements in patients with HD 3,4 , demonstrating the contribution of DA to motor dysfunction
