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When artesunate and chloroquine are combined, they can regulate macrophages, inhibit the proliferation of colon cancer (HCT 116 and CT26) cells, and reverse the immunosuppressive tumor microenvironment [176]

[PMC free article: PMC6240904] [PubMed: 30335147] 6

These cellular aspects are subsequently discussed in relation to pathological glutamine homeostasis of hepatic encephalopathy, epilepsy, Alzheimers disease, Huntingtons disease and amyotrophic lateral sclerosis

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