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The therapeutic window for selenium is limited, and long-term consumption of more than 400 g/day can cause selenosis, which manifests as gastrointestinal issues, brittle nails and hair, dermatological changes, and infrequently, neurological problems [19]

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The mitochondrial AST enzyme is encoded by the GOT2 gene which is located on chromosome 16q21 and is composed of 10 exons that generate two alternatively spliced mRNAs encoding precursor proteins of 430 amino acids (isoform 1) and 387 amino acids (isoform 2)

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