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Intramuscular (IM) vitamin injections bypass the gastrointestinal system entirely, achieving 70 to 80% greater bioavailability than oral supplementation
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The most commonly reported adverse events associated with the use of dihydroergotamine mesylate nasal spray during placebo-controlled, double-blind studies for the treatment of migraine headache and not reported at an equal incidence by placebo-treated patients were rhinitis, altered sense of taste, application site reactions, dizziness, nausea, and vomiting