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TMAO and NF-B signaling NF-B is a master regulator of inflammation, and its activation by TMAO has been extensively documented
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Neurochem Res 29 , 19231930 (2004)
PMC 5986421

doi: 10.1038/s41420-020-00309-8 8 GongXLiuYLiuXLiAGuoKZhouDet al

The body's regulation of NO production is complex, with multiple feedback mechanisms, and simply providing more substrate may not overcome underlying pathological processes causing ED