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When FOXO activity decreases in activated NSCs, metabolism shift toward lipogenesis and oxidative phosphorylation (OXPHOS), leading to ROS signalling that promotes neuronal differentiation (Ludikhuize and Rodriguez Colman, 2021)

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To evaluate KL1 adjuvant activity in vivo, mice (male:female = 1:1) were infected with 2 10 7 c.f.u.s of strain HG003 via intravenous injection

This conclusion directly corroborates the findings of Shafie et al