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However, some cell type- and age-related global DNA methylation showed independent of MTHFR genotypes

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This duality in p53 function with ROS intensity may decide the cell fate, with the protective arm of p53 activating processes to reduce cell stress with lower ROS intensity, while higher ROS intensity tips the balance towards cell death

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However, strengths of the study include the community-based recruitment, the unmedicated and mostly medication-nave MDD group, and the relatively large control sample that matched MDD cases in terms of education and other sociodemographic variables [7]

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