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In contrast, the same glargine administration program failed to improve these metabolic abnormalities in Atm -KO mice, indicating that ATM is crucial for insulins systemic metabolic effect and the loss of ATM leads to these metabolic abnormalities

Pyroptosis-related DEGs were obtained by intersecting the DEGs identified from the four datasets with pyroptosis-related genes

USA 93 , 37043709 (1996)

C., Babovic-Vuksanovic, D., Dombi, E., Wolters, P

Taken together, our findings reveal a novel adipocyte Ssu72-GSK3 axis that regulates obesogenic adipogenesis in white adipocytes, suggesting that Ssu72 is a promising target for controlling diet-induced obesity and whole-body metabolic homeostasis