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Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice

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However, overexpression of GDF11 effectively mitigated these adverse effects, restoring vascular integrity (Fig

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It upregulates genes for extracellular matrix proteins and growth factors and downregulates proinflammatory genes

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This consistency matters enormously for preserving lean mass during weight loss, a challenge that intensifies as body composition shifts

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