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Through oxidative metabolism, they convert substrates such as glucose, fatty acids, and amino acids into ATP to sustain cellular functions, while also participating in key processes including apoptosis, calcium signaling, immune responses, and redox balance [40]

Among these, lipid-based nanocarriers have gained much attention due to their safety, stability, cost-effectiveness, high encapsulation efficiency, and suitability for surface brain targeting modification

The misuse or abuse of gabapentin, on the other hand, can lead to dependence with withdrawal symptoms comparable to those from benzodiazepines and alcohol: anxiety, insomnia, nausea, pain, excessive sweating, tremors, headaches, depression, feeling abnormal, dizziness and malaise [58]

A systematic review on synthetic drugs and phytopharmaceuticals used to manage diabetes

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