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Chelating agents can mitigate oxidative stress-induced diseases by reducing free iron ion levels and preventing ROS generation

Grossmann M, Wierman ME, Angus P, Handelsman DJ

Concomitant antidiabetic therapies were frequently reported, with metformin being the most frequently reported concomitant medication (n = 1,879), followed by pioglitazone (n = 478), insulin glargine (n = 474), glipizide (n = 467), and glimepiride (n = 345) (Figure S1)

Interestingly, while the renal content of NAM is only slightly decreased and NR is not modified in the kidneys of cKOt mice, there was an approximately 30% reduction in NMN levels

Tay C, Grundy L

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