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2,3 In REDEFINE 1, adverse events were mainly gastrointestinal, (79.6% in the CagriSema group vs 39.9% with placebo) including nausea (55% vs 12.6%), constipation (30.7% vs 11.6%), and vomiting (26.1% vs 4.1%)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 107.Dub JJ, Sitnick MT, Schoiswohl G, Wills RC, Basantani MK, Cai L, et al

All of this happens before patients notice anything

During the first week after treatment, sleeping in an elevated position is crucial

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