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however, this finding has not been followed up by intervention trials in humans

10.1097/00003086-199305000-00038 [DOI] [PubMed] [Google Scholar] Kawakami T., Kawai T., Takei N., Kise T., Eda S., Urist M

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ABCB1 , another drug resistanceinducing gene, was knocked down using CRISPR/Cas9 in one study, resulting in enhanced drug sensitivity in adriamycin-resistant ovarian cancer cell lines (29)

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Rapid weight loss creates specific challenges that the medication itself does not solve