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One possible method of overcoming this problem would be the use of 13 C hyperpolarization, a recently developed method of increasing the polarization of molecules thus increasing overall SNR by several orders of magnitude

Vignoli A, Sticchi E, Piccardi B, Palumbo V, Sarti C, Sodero A, Arba F, Fainardi E, Gori AM, Giusti B, et al