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For example, it is often forgotten that although the canonical role of LPL is the hydrolysis of TGs within TRLs, LPL also has phospholipase A 1 activity ( P -nitrophenyl butyrate (PNBP) was initially developed as a short-chain fatty acid (SCFA) substrate for LPL ( p -nitrophenyl acatate in the absence of ApoC-II ( In the search to identify more physiologically relevant non-lipoprotein substrates, several TG analogs were developed where the lipolytic products could be visualized, and hence LPL activity, quantified by fluorescence ( sn-1 position, this is subject to hydrolysis by LPL and HL, and therefore nAngptl4-mediated inhibition of LPL is a requisite control

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