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Farge T, Saland E, de Toni F, Aroua N, Hosseini M, Perry R, et al

(PubMed) Diez-Ricote L, San-Cristobal R, Concejo MJ, et al

Melanotic neuroectodermal tumour of infancy of the jaws: an analysis of diagnostic features and treatment

Reportedly, PTEN loss in melanoma is a frequent event, occurring in about 30% of primary tumors, with an even higher frequency in melanoma cell lines ( The TP53 gene is considered the guardian of the genome due to its pleiotropic function in protecting cells from genotoxic damages, acting as tumor suppressor and transcriptional activator/repressor of several downstream genes controlling cell-cycle progression, DNA repair, and also triggering apoptosis ( TP53 mutations have been reported in about 15% of TCGA cases, they are mostly ultraviolet (UV) radiation-induced, and lead to tumor initiation and progression