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First, because 4MP causes considerable phospho-JNK inhibition which negatively impacts p53 activation and necrosis 92 , we considered that 4MP causes a conservative 80% decrease of p53 activation and simulated this by multiplying the phosphorylation rate of p53 with parameter k 4MP JNK = 0.2 (i.e., decreasing the phosphorylation rate)

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Nazir, 2024)

[DOI] [PubMed] [Google Scholar] Meyer MR, Holderbaum A, Kavanagh P, and Maurer HH (2015) Low resolution and high resolution MS for studies on the metabolism and toxicological detection of the new psychoactive substance methoxypiperamide (MeOP)

How to Maximize Glutathione Absorption Cooking methods significantly impact the glutathione content and bioavailability of foods

Furthermore, the same polymorphism was found to be over-represented in patients developing acute liver injury following high doses of paracetamol taken unintentionally over several days [39]