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Research has shown that also the insulin-like growth factor 1 (IGF-1) haplotype plays a critical role in determining size differences in dogs, with smaller breeds exhibiting lower levels of IGF-1, which may contribute to their increased longevity [67]

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Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, et al

10.1186/s12882-021-02328-8 [DOI] [PMC free article] [PubMed] [Google Scholar] Beulens J

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