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AZD6244 (Selumetinib), a MEK1/2 inhibitor showed efficacy in BT-40 xenografts, highlighting the MEK signaling pathway as a potential therapeutic target (51)
10.1016/0047-6374(76)90012-9 104 SinghP.GollapalliK.MangiolaS.SchrannerD.YusufM
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Further mechanistic investigations demonstrated that TMAO induced NAFLD includes the activation of the PERK signaling pathway (Figure 2) and inhibition of the farnesoid X receptor signaling [14, 85]
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