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When NNMT is overactive in adipocytes, SAM is depleted reducing the cells capacity for methylation reactions that regulate gene expression, including the epigenetic programs that control energy expenditure

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Research Findings 5-Amino-1MQ is a selective Nicotinamide N-Methyltransferase (NNMT) inhibitor that has emerged as a significant research tool for investigating metabolic regulation and cellular energy homeostasis