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Furthermore, this capability could significantly aid patient counseling and expectation-setting
In addition to serine phosphorylation of the insulin receptor, various PKC isoforms have been shown to phosphorylate IRS1 and IRS2 further impairing the ability of these insulin receptor substrates to associate with the insulin receptor and downstream effector proteins such as PI3K
Therefore, a necessary condition for resistant cancer cells is elevated levels of intracellular ATP (41, 56)
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