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pneumoniae remains a significant public health concern, with reports indicating it is responsible for over 1.2 million deaths annually, primarily affecting young children and the elderly ( Furthermore, the increasing antibiotic resistance of this pathogen poses substantial challenges to the treatment of invasive pneumococcal diseases

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[111] targeted N-to-B delivery of thyrotropin-releasing hormone (TRH)(a polypeptide used for treating suicidal patients), using fast degrading poly(sebacic anhydride) (PSA) NPs

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